Muhammad Ali Memon, Habibullah Quershi, Saleh Memon.
Amino acid variations in urine of urinary tract infection patients
J Liaquat Uni Med Health Sci Sep - Dec 2006;5(3):98-101.
Liaquat University of Medical & Health Sciences, Jamshoro, Sindh

BACKGROUND/OBJECTIVES: Majority of urinary tract infection (UTI) patients received at Liaquat University Hospital Jamshoro and Hyderabad belong to adjoining rural areas of Sindh province. As only reliable clinical laboratory test available for diagnostic purpose is urine culture and sensitivity which is lacking in these areas due to complexity of tests, expertise and non-availability of electric facility. Hence, present study was conducted to device alternate method, which must be simple, easy and does not require much expertise. PATIENTS AND METHODS: In all, 106 patients and 25 normal controls were selected for this study. Morning urine samples were collected and analyzed for amino acids by paper chromatography using two different solvent systems. RESULTS: Different amino acids were found missing in urine of UTI patients. Greater percent of them was aromatic amino acids like tryptophan (90.56%), phenylalanine (71.69%), tyrosine (70.75%) and methionine (91.5%). CONCLUSION: Ordinary urine chromatographic separation test of amino acids shows aromatic and essential amino acids absent from urine, which can provide basis for screening test of UTI in areas with lesser facilities.

Category: Biochemistry
Keywords: Chromatography. Urinary Tract Infection. Amino Acids.

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