Rubina Aziz, Tabassum Mahboob.
Pre-eclampsia and lipid profile
Pak J Med Sci Oct - Dec 2007;23(5):751-4.
University of Karachi, Karachi
Objectives: The present study was designed to evaluate the role of lipid profile alteration in the development of Pre-eclampsia. Methodology: We selected 32 pregnant women, 16 healthy pregnant women (mean age 25.56±3.68) as normal and 16 already diagnosed preeclamptic women (mean age 24.65±4.25) as study group. Serum lipid profile (total lipids, cholesterol, triglycerides, HDL-cholesterol and LDL- cholesterol) of thirty two women with Pre-eclampsia (n=16), normotensive women (n=16) were monitored. Results: The serum triglyceride concentrations increased significantly (232.18±106.41 vs. 113.12 ±21.3, P<0.01) while Serum HDL- cholesterol concentrations decreased significantly (39.75±11.99 vs. 51.18±06.09, P<0.01) in preeclamptic group as compared to normal pregnant women. Conclusion: Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia. Increased triglycerides levels along with decreased HDL-cholesterol levels and delayed triglycerides clearance and high blood pressure are associated with development of preeclampsia.
Category: Obstetrics and Gynecology
Keywords: Eclampsia. Cholesterol. Lipids. Lipoproteins.
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