Foad Ali Moosa, Mohammad Sohail Choudhry, Fazal Wahab Khan, Montasir Junaid, Naheed Sultan.
Experience of Octreotide in the management of post operative Enterocutaneous fistulae
J Surg Pak Sep 2007;12(3):115-8.
Civil Hospital and Dow University of Health Sciences, Karachi

Objective: To evaluate the effectiveness of octreotide in the management of postoperative gastrointestinal (GI) fistulae. Study Design: Interventional study. Place & Duration of study: This study was carried out at Surgical Unit-2, Civil Hospital, Karachi, from July 2002 to December 2006. Patients & Methods: A total number of 26 Patients who presented with gastrointestinal fistulas after surgeries for trauma, firearm injury, abdominal tuberculosis, and typhoid perforation were included whereas, patients with GI malignancy, history of radiation and distal obstruction were excluded from the study. All were patients initially were managed conservatively. We divided 26 patients into two equal groups; 13/26 patients were on TPN alone, and 13/26 were on TPN and octreotide. Results: The male: female ratio was 1.6:1. Mean age of the patients was 33.9+ 2.5 years having a range of 12-60 years. Six (24%) patients underwent repeat surgery in an average 02 weeks post-operatively due to failure of conservative management and the remaining 20 (76%) were continued on conservative management for a period of 3-9 weeks, and success in regards of early closure time (within 06 weeks) was observed in cases kept on TPN plus octreotide (83.3%). Conclusion: Results were markedly improved with combination of TPN and octreotide in high lying fistulas as compared to TPN alone.

Category: Surgery
Keywords: Fistula. Octreotide. Enterocutaneous Fistula.

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