Kiren K Malik, Noreen Akmal, Naseem Akhtar.
Co-relation of Lactic Dehydrogenase levels with severity of Pre-Eclampsia
Biomedica Jul - Dec 2007;23:107-10.
Social Security Teaching Hospital, Lahore

The elevated levels of LDH may reflect the severity of pre-eclampsia and occurance of complications. This study was carried out as a comparative study at Social Security Teaching Hospital, Lahore from June 2004 to January 2006: A total of 120 pregnant women with preeclempsia (60 with mild and 60 with severe pre-eclampsia) and 60 healthy normotensive controls were included in the study. The total number of deliveries during the same period was 5402. The patients were divided in three groups after admission through outpatient and emergency departments. Group I: (n-60) third trimester healthy pregnant women. Group II: (n-6o) women with mild pre-eclampsia. Group III: (n-60) women with had severe pre-eclampsia. The three groups were matched according to the age, parity, gravidity, maternal weight, haemodyanamic and laboratory tests. A statistically significant difference in terms of age, weight and parity were noticed in 3 groups p <0.05. Primigravida were 20% in normotensives, 40% were with mild pre-eclampsia and 60% with severe pre-eclamptia. In comparison of group II & III (severe pre-eclampsia) showed a statistically significant increase in terms of LDH and liver enzymes (p<0.05) in group III. LDH levels >600 IU/l were seen in 62% of women with severe pre-eclampsia compared to i0% in group I & II woman. LDH concentrations >800 IU/1 had significant increase in frequency of epigastric pain and vomiting and no significant difference in other system. Severe pre-eclampsia with LDH >800 IU/l women had significant increase in all complications noticed, eclampsia being the most frequent one. Elevated levels of LDH, indicative of cellular damage, can be used as a biochemical marker because it reflects complications and foetal outcome.

Category: Obstetrics and Gynecology
Keywords: Lactic Dehydrogenase. Eclampsia. Pregnancy Induced Hypertension.

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