Nadeem Sajjad Raja.
Gastrointestinal Histoplasmosis in a non-human immunodeficiency virus patient: a case report
Infect Dis J Dec 2007;16(4):115-8.
University of Malaya Medical Centre, Kuala Lumpur, Malaysia
and Review of Literature We report a rare case of an immunocompetent 70-year-old male from Malaysia who developed disseminated gastrointestinal histoplasmosis. He developed progressive weight loss, diarrhoea and vomiting over six months. The diagnosis was made on the basis of isolation of Histoplasma capsulatum from blood and morphological features of Grocott-Gomori methenamine silver nitrate staining of tissue from the colon. The initial antifungal therapy was parenteral amphotericin B that was later substituted with oral itraconazole. Our patient was a unique sporadic case of gastrointestinal histoplasmosis (disseminated) without Human Immunodeficiency Virus infection and did not have any history of malignancy, chemotherapy or use of corticosteroids. We also review the main epidemiological, clinical, diagnostic and therapeutic characteristics of gastrointestinal histoplasmosis.
Category: Case Reports
Keywords: Histoplasmosis. Fungal Infections. Immunodeficiency Virus. Histoplasma Capsulatum.
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