Mazhar Iqbal, Inamullah, Zahid Mehmood, Shoaib Malik, Iram Bokhari, Asadullah Khan.
Role of preemptive analgesia in laparoscopic cholecystectomy
J Surg Pak Jul - Sep 2009;14(3):132-5.
Jinnah Postgraduate Medical Centre, Karachi

Objective: To compare the effect of preemptive analgesia with post operative analgesia using diclofenac sodium in female patients undergoing laparoscopic cholecystectomy. Study design Descriptive study. Place & duration of study: Study was conducted in surgical ward 3, Jinnah Postgraduate Medical Center Karachi from January 2007 to December 2008. Patients and Methods: This study was carried out on two hundred patients, divided into 2 comparable groups. Group I. included 100 patients in whom post operatively injection diclofenac sodium was given without any preemptive analgesia. In group II, of 100 patients diclofenac sodium 100 mg suppository was given after induction. Same anesthesia drugs were given to all the patients. Verbal rating scale was explained to patients during pre-anesthesia consultation. Post operatively pain was assessed by verbal scale and Results: were recorded and comparison done between two groups. Results: Most of the patients in group I experienced moderate pain (n 80) and severe pain (n 20) and requirement for analgesic drugs was also more in this group. In group II diclofenac sodium suppositories were used for preemptive analgesia. Post operatively most of the patients experienced no pain to mild pain (n 90), and post operative analgesic requirement was also less. Conclusions: Preemptive analgesia in female patients who underwent laparoscopic cholecystectomy with diclofenac sodium was effective in blocking noxious stimuli and central sensitization, with subsequent prevention of acute post operative pain.

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