M T MALIK, R S CHUGHTAI, N A MALIK, S HASSAN.
Anti-Convulsive Effect of Beta Blockers: Antagonism of Strychnine Toxicity
Ann King Edward Med Coll Jul - Sep 1998;4(3):13-5.
Department of Experimental Pharmacology, KEMC Lahore

Anti convulsive property possessed by Beta Adrenergic Blocking agent against drug induced convulsions was studied, in the Department of Experimental Pharmacology. White mice were used as experimental animals. Strychnine Hydrochloride was injected intra peritoneally in preliminary experiments and the strychnine LD100 was determined. One group (n = 6) served as control, whereas four other groups (n = 6) were pre-treated with Propranolol, Timolol, Atenolol and Labetalol, in a dose of 411 mg/kg subcuntaneously, 30 minutes before strychnine injection. The protective effect of Propranolol was marked. Timolol and Atenolol did not exhibit anti-convulsive activity. Labetalol, had a worsening effect on the convulsive state; which could be due to its additional alpha-receptor blocking activity.

Category: Pharmacology
Keywords: Beta Blockers. Drug Induced Convulsions. Anti-Convulsants.

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