Cheema Z F, Khana S, Akram Y, Nations S.
Leprosy: Immunopathology, neurologic manifestations and treatment
J Pak Med Assoc Dec 2003;53(12):615-8.
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Leprosy caused by Myobacterium leprae, an acid-fast bacillus is a chronic infection affecting skin and peripheral nerves. It is a significant cause of morbidity in endemic areas. Peripheral neuropathy is a common manifestation of the disease and involves dermal and superficial peripheral nerves. The pathologic expression of diseases depends on the host response to M. leprae and ranges from tuberculoid leprosy to lepromatous leprosy. The latency of the infectious agent poses a challenge for diagnosis and long-teen management especially in patients with pure neuritic form without skin lesions. Leprosy reaction is as important cause of neurologic disability in established patients. The diagnosis should be considered in patients from endemic areas presenting with peripheral neuropathy with or without skin lesions. This is a review article.

Category: Internal Medicine
Keywords: Leprosy. Myobacterium Leprae. Neuropathy.

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