Sadia Saeed, Samia Ahmad, Sheikh Ajaz Rasool.
Antimicrobial spectrum, production and mode of action of Staphylococcin 188 produced by Staphylococcus Aureus 188
Pak J Pharm Sci Jan 2004;17(1):1-8.
Department of Microbiology, University of Karachi, Karachi
Staphylococcus aureus 188 has been shown to produce bacteriocin-like inhibitory substance known as staphylococcin188. It has a broad-activity spectrum against Micrococcus luteus, Streptococcus pneumoniae, Streptococcus faecalis, Streptococcus viridans, Corynebacterium diphtheriae and several staphylococcus species. The arbitrary unit of staphylococcin 188 against Micrococcus luteus was 1280AU/mL. Its production with simultaneous measurement of activity was monitored and was found to produce maximum amount of staphylococcin after 7 hours of incubation. Mode of action of the staphylococcin 188 on the sensitive cells was bactericidal rather than bacterioloytic.
Category: Microbiology
Keywords: Staphylococcus Aureus. Gram Positive Bacteria. Staphylococcin. Bacteriocin.
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