Mohammad Amjad Taqweem, Intekhab Alam, Mohammad Athar Taqweem, Arshad Javed.
Comparison between bronchodilator effects of intravenous Aminophylline vs nebulised Salbutamol in acute severe Asthma
J Postgrad Med Inst Jun 2004;18(2):316-20.
Department of Medicine and Department of Pulmonology, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar
Objective: To compare effects of and to compare iv aminophylline with Nebulized salbutamol in the management of acute attack of bronchial asthma. Material and methods: This prospective study was done on a selected group of Ten patients who presented to the Pulmonology unit with acute attack of bronchial asthma. Both the drugs were tried on two different occasions and their efficacy in relieving the symptoms and on improving the pulmonary functions tests were studied. Results: Both the drugs were found to be effective in relieving the symptoms (p=<0.05). However nebulized salbutamol was found more effective than iv aminophylline (p=<0.05). salbutamol appears to be marginally letter than Aminophyllin. A larger randomized study is needed to document this. Conclusion: Because of its better efficacy and less toxicity nebulised salbutamol stays the drug and method of choice in the management of acute attack of bronchial asthma.
Category: Internal Medicine
Keywords: Salbutamol. Aminophylline. Asthma.
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USER COMMENTS
Very good study,the limitition is the number of patients,still its representative sample.Its well proven now that Salbutamol is superior to Aminophyllin(as first line drug in acute exaserbation of asthema)in many respects.
Posted by: asadrahman on Apr 2006
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