Taj Ali Khan, Suhaib Ahmed, Masood Anwar, Mohammad Ayub.
The frequency of Glucose-6 Phosphate Dehydrogenase deficiency in Punjabis and Pathans
J Postgrad Med Inst Oct - Dec 2004;18(4):592-7.
Lady Reading Hospital, Peshawar, PNS Shifa, Karachi and AFIP Rawalpindi
Objective: To find the frequency of Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency in healthy young adult male population of various ethnic groups and sub-groups of Punjabis and Pathans. Material and Methods: This Cross-sectional comparative study in Armed Forces Institute of Pathology, Rawalpindi, from Jan-Dec 2000. Eight hundreds apparently healthy unrelated adult males (Punjabis: 400 and Pathans: 400) were screened for G6PD deficiency by a commercial qualitative screening test kit. Result: Out of 800 subjects, 47 (5.9%) were G6PD deficient (95% CI: 4.2-7.5%). The frequency in Pathans (8.3%) was significantly higher than in Punjabis (3.5%) (p=0.006). There were also differences in the frequency of G6PD deficiency among the sub groups of Punjabis and Pathans. Conclusion: G6PD deficiency is a fairly common abnormality in Punjabis and Pathans. Such individuals are highly susceptible to develop acute haemolytic episodes by a variety of stimuli including some of the commonly used drugs.
Category: Haematology
Keywords: Glucose 6 Phosphate Dehydrogenase Deficiency. G6PD. Hemolysis. Anemia.
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