Aminul Haq, Azra A Ghani, Taskeen Ahmad Khan, Isa Khan.
Complete Androgen blockade in advanced Prostate Cancer: a clinical experience
J Postgrad Med Inst Oct - Dec 2004;18(4):598-601.
Department of Urology, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar

Objective: To evaluate the clinical and biochemical outcome of patients with advanced prostate cancer treated by complete androgen blockage (CAB). Material and Methods: A total number of thirty patients with histologically confirmed advance prostate cancer and serum PSA level of more than 30ng/ml were subjected to bilateral subcapsular orchidectomy, supplemented with oral antiandrogens. These patients were followed for a period of two years by recording their symptoms and serum PSA level at twelve weeks intervals. Results: Only 16(53.33%) patients complied with the protocol of the study and observed two years followup. 12(75%) patients showed complete response to CAB while 4(25%) patients showed rising PSA levels and became symptomatic after one year of treatment. Conclusion: CAB is still the treatment of choice for patients with advanced prostate cancer.

Category: Oncology
Keywords: Prostate Cancer. Prostate. Androgen Blockade. Androgens. Cancer.

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