Masoumeh Sadeghi, Hamid Raza Roohafza.
Serum lipid distribution and prevalence of Dyslipidemia in urban and rural communities in Iran - IHHP study
Pak J Cardiol May - Aug 2004;15(2):88-94.
Isfahan University of Medical Sciences, Isfahan, Iran

Introduction: Hyperlipidemia is one of the main underlying causes of cardiovascular diseases. This study was designed to assess lipid profiles according to sex and place of residence in Iran. Methods: This descriptive study is an analysis of the first phase of Isfahan Healthy Heart Program, which was conducted in Isfahan and Najaf-abad. The inclusion criteria consisted of Iranian nationality, having lived in above cities longer than six months, and absence of chronic diseases, mental retardation or pregnancy. Sampling was conducted using the randomized cluster method. In addition to collecting demographic data (age, sex, smoking, drug use and menopause), the questionnaire checked the results of paraclinical tests (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density liporotein cholesterol (LDL-C), triglycerides (TG) and the body mass index (BMI). The collected data were analyzed with tstudent, one-way ANOVA, and chi- square tests. Results: Of 3988 individuals over 30 years, 52.4% were female and 47.6% were male. 79% and 21% lived in urban and rural area respectively. In both male and female significant difference was seen in respect of various types of dyslipidemia. After matching the subjects for age, smoking, BMI, and menopause, it was observed that elevation of TC and LDL-C levels and the decrease in HDLC level were more prominent in female, and the increase in triglycerides level was more marked in male (p<0.0001). LDL-C and triglycerides disorders were seen more frequently in urban and rural area, respectively (p<0.0001). Dyslipidemia became more prevalent with aging in both sexes. In female, dyslipidemia was more prevalent at older age. Conclusion: The high prevalence of dyslipidemias may be accounted by unhealthy lifestyle, unhealthy nutrition, and inadequate physical activity in Iranian people. Hence, lifestyle modification can reduce the prevalence of dyslipidemias and cardiovascular diseases.

Category: Biochemistry
Keywords: Lipids. Cholesterol. Dyslipidemia.

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