Nadir Ali, Masood Anwar, Mohammad Ayyub, Farhat Abbas Bhatti, Mansoor Nadeem, Asif Nadeem.
Frequency of Glucose-6-Phosphate Dehydrogenase deficiency in some ethnic groups of Pakistan
J Coll Physicians Surg Pak Mar 2005;15(3):137-41.
Combined Military Hospital, Attock and Armed Forces Institute of Pathology, Rawalpindi

Objective: To determine the frequency of G6PD deficiency in young healthy adult males of some ethnic groups in Pakistan. Design: Descriptive study. Place and Duration of Study: Study performed in Combined Military Hospital, Attock in collaboration with Armed Forces Institute of Pathology, Rawalpindi from October 2003 to January 2004. Patients and Methods: Asymptomatic and healthy adult males were included in the study. A brief clinical record including age, ethnic group, place of residence, and history of past illnesses including fever, episodes of recurrent jaundice were recorded. Met-hemoglobin reduction test for G6PD screening was performed. Hemoglobin, red cell indices and total leukocyte count of G6PD deficient cases were measured on Sysmex KX 32 hematology analyzer. Results: Three thousand adult males with age between 17 years to 23 years were screened. G6PD deficiency was detected in 1.8%. Deficiency state was 1.07% in Kashmiris, 1.47% in Punjabis, 2.77% in Sindhis, and 3.17% in Pathans. Past history of recurrent jaundice was present in 5.7%. Mild anemia was present in 3.8%. Conclusion: Frequency of G6PD deficiency was 1.8% in young healthy adults with insignificant difference among various ethnic groups except in Pathans.

Category: Haematology
Keywords: G6PD. Hemolysis. Anemia.

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