Muhammad Akram Randhawa, Omar Mohammad Alakloby, Salih Hamad Mohamad Aljabre, Abdulrahman Mohamad Alqurashi, Naeem Akhtar.
Thymoquinone, an active principle of Nigella sativa, inhibited Fusarium solani
Pak J Med Res Jan - Mar 2005;44(1):1-3.
College of Medicine, King Faisal University, Dammam, Kingdom of Saudi Arabia

The response of infections with Fusarium species to treatment with antifungal drugs is generally poor and unpredictable. In the present study the anti-fungal activity of thymoquinone, an active principal of Nigella sativa, was investigated against fresh cultures of Fusarium solani (F. solani) isolated from the toe nail of a patient. F. solani was cultured on dermasel agar containing 0.125, 0.25, 0.5 and 1 mg/ml of thymoquinone and on dermasel agar alone as a control. After 10 days of incubation at 30° C, in the presence of these concentrations of thymoquinone, there were 10.5, 32.2, 54.7 and 100% inhibition of the growth of F. solani, respectively. Thus the minimal inhibitory concentration (MIC) was 1mg/ml. The results of this preliminary study showed that thymoquinone exhibited antifungal activity against F. solani.

Category: Pharmacology
Keywords: Thymoquinone. Nigella Sativa. Fusarium Solani.

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