Fawad Qureshi, Faisal Qureshi, Anjum Q, Sarwar Jehan Zuberi.
Is the high frequency of diabetes type 2 in chronic hepatitis C virus infection due to strong family history?
J Ayub Med Coll Abottabad Apr - Jun 2005;17(2):90-1.
Division of Medicine, Ziauddin Medical University and Hospitals, Karachi

A total of 212 patients with DM type 2 were retrieved, out of which 100 were HCV positive and 112 were HCV negative. HCV was detected either by detection of antibodies to HCV or HCV RNA in the serum. Family trees were drawn on each patient with emphasis on history of DM type 2 in any family member. According to this, two groups: one with HCV positive and the other group with HCV negative patients were made. Each group was divided into five categories as follows. 2 patients from HCV negative group were excluded as their parents adopted them and therefore family history was not available. RESULTS: Out of selected cases, 100 were HCV positive and 112 were HCV negative. In both the groups, 68% patients were males, and there was no significant difference between males and females (p=0.98) ratio in the two groups. Mean age was 46 years in both groups (range 30-74 years in group 1) vs (range 26-70 years in group 2). There was no significant difference in history of DM among both or one parents in both the groups (p=0.18). On the other hand, a significant difference was observed in history of DM in siblings in the two groups (p=0.026). CONCLUSIONS: We found that DM type 2 occurred with increasing frequency among patients with Hepatitis C. In our group of patients, we explained that increased occurrence was associated with family history of DM. This variable effect may be one of the reasons of higher frequency of DM type 2 in this group of patients. A prospective study comparing the incidence and prevalence of DM type 2 in HCV infected and non-infected patients are warranted which may further detect other variables explaining this effect.

Category: Internal Medicine
Keywords: Diabetes Mellitus. Hepatitis C. Hepatitis.

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