Nargis Jamil, Mohammad Shafiq, Kausar Tasneem, Ghosia Lutfullah, Jamil ur Rehmnn.
Glycohemoglobin and Incidence of Coronary Heart Disease
J Ayub Med Coll Abottabad Apr - Jun 2000;12(2):10-1.
Department of Biochemistry, Khyber Medical College, Peshawar

Background: Presence of glucose on HbA1-C is established and represents a post translational glycosylation by a slow non-enzytnatic process occurring during the 120 days life span of RBCs. It is an indicator of long term glycemic control. Glycohemoglobin is directly related to blood glucose level. Methods: 50 randomly selected diabetic patients were included quid divided into two groups B and C of 25 subjects each. The subjects of group C were the diabetics who were confirmed cases of CHD, while group B were the diabetics without any complications, Group A consisted of healthy controls (n=25). Glycohaemoglobin was determined by column chromatography while blood glucose was estimated by enzymatic method. Results: Blood glucose was increased in both the patient groups (p<0.001). Comparison of HbA1-C revealed a highly significant rise (p<0.001) in both the groups against normal control subjects of group A. Correlation of HbA1-C with glucose in all the three groups was directly positive (r=+0.4). Conclusions: The results of the present study suggest an association between HbA1-C hyperglycemia and the incidence of CHD in diabetics.

Category: Biochemistry
Keywords: Glycohemoglobin. Ischemic Heart Disease. HbA1-C.

Click here for Full Text Article

This article has been viewed 589 times

Submit your Research Synopsis for Free Expert analysis - Search- Feedback - Drug Index
Post and View Comments on this Article