Saida Haider, Anila Yasmeen, Tahira Parveen, Darakhshan J Haleem.
Neurochemical and behavioural effects of long term intake of tea
Pak J Pharm Sci Jul 1998;11(2):55-60.
University of Karachi, Karachi
Tea consumption in many cases is the main source of caffeine intake in humans. In the present study neurochemical and behavioural effects of long-term tea intake are monitored in rats. Long-term tea administration did not alter plasma tryptophan (TRP) but signifi¬cantly attenuated brain TRP and 5-hydorxtryptamine (5-HT, serotonin) levels. Brain 5-hy-droxyindole acetic acid (5-HIAA) was comparable in both tea-treated and control rats. An increase in home cage activity was observed after one week in rats taking tea as sole source of liquid, whereas no change on the activity was observed in an open field. Caf¬feinism has been associated with depression. The decreases of brainmonoamine metabo¬lism observed in present study are discussed as lowering of mood observed in tea or cof¬fee consumers
Category: Pharmacology
Keywords: Neuropharmacology. Tea.
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