Saify Z S, Faiyaz H M Vaid.
Synthesis and anti-microbial screening of some Piperidine derivatives
Pak J Pharm Sci Jan 1998;11(1):15-21.
University of Karachi, Karachi
Synthesis of piperidine derivatives viz, l-(4`-methoxy phenacyl)- N-Methyl piperidinium bromide, and 1-(4`- nitrophenacyl)-N-methyl piperidinium bromide, and l-(3`, 4`-dihydroxy phenacyl)-N-methyl piperidinium chloride was carried out by quarternizing N-methyl piperidine with corresponding phenacyl halides. The structures of these compounds were elucidated by spectroscopic techniques such as UV, IR, El mass and 1H-NMR. The compounds were subjected to antimicrobial screening in quantities of 10 mg/ml dissolved in DMSO. Disc diffusion method was used to observe the significance of these compounds against seven bacterial and one fungal cultures.
Category: Pharmacology
Keywords: Piperidine.
Click here for Full Text Article
This article has been viewed 283 times
Download in Citation Manager - Print - Email - PakMediNet Member Services Submit your Research Synopsis for Free Expert analysis - Search- Feedback - Drug Index
Post and View Comments on this Article
