Dileep Kumar Rohra, Ali Jawaid, Tauseefur Rahman, Ali Hyder Zaidi.
Reliability of rodent animal models in biomedical research
J Coll Physicians Surg Pak Dec 2005;15(12):809-12.
The Aga Khan University, Stadium Road, Karachi

Despite the discrepancies observed between the data generated from humans and animals, it is a usual practice that the results obtained from animal models are extrapolated on humans. This review stressess that while animal models are essential for the research and development, a critical caution needs to be practiced in interpreting the results. Uncritical reliance on the results of animal experimentation can be dangerously misleading and has resulted in damages to human health in several cases. This review also discusses the role of certain confounding factors in using animal models due to which appropriate precautions need to be taken while deciding to conduct a study using animal models and caution is warranted in extrapolating the data obtained from pre-clinical studies on humans.

Category: Physiology
Keywords: Animals. Genetics. Biomedical Research.

Click here for Full Text Article

This article has been viewed 338 times

Submit your Research Synopsis for Free Expert analysis - Search- Feedback - Drug Index
Post and View Comments on this Article