Sadreddini S A, Abolfathi A A, Khandaghi R, Talebi M, Lakian A.
C-Reactive protein, fibrinogen, LP (a), lipid profile levels and platelet count in patients with ischemic stroke
Pak J Neurological Sci Jun 2006;1(1):7-13.
Tabriz University of Medical Sciences and Health Services, Tabriz, Iran

Background & objective: Stroke is a leading cause of morbidity and mortality in most developed nations. Various risk factors are associated with stroke. The aim of this study was to determine the prevalence of various risk factors. Methods: This study was performed as a descriptive and analytical prospective study of patients with stroke admitted to our hospital during the years 2002-2003. A total of 100 ischemic stroke (IS) patients (46 male and 54 female; mean age 67 ± 15 years) and 100 age- and sex-matched apparently healthy subjects were studied. Plasma levels of C.-reactive protein (CRP), fibrinogen, platelet count, lipoprotein (a) (Lp(a)), high density lipoprotein cholesterol (HDL- c), low density lipoprotein cholesterol (LDL-c), total cholesterol (TC) and triglycerides (TG) were measured in patients and controls. Background disease was also investigated in the patients. Results: Mean plasma levels of LP (a), TC, TG, CRP and LDL-c were significantly higher in IS group compared with controls (p< 0.05). There was no significant difference for HDL-c and platelet count (p > 0.05). The prevalence of background disease in IS patients was as follows: hypertension (78%) hyperlipidemia (62%) cardiovascular disease (38%) type 2 diabetes mellitus (24%), smoking (20%) and previous stroke (18%). Conclusion: It was concluded that hypertension is the most prevalent background disease in IS patients. It was also found that there is a close relationship in incidence of IS with levels of LP (a), TC, TG, LDL-c and CRP.

Category: Neurology
Keywords: C Reactive Protein. Fibrinogen. Lipoproteins. Lipids. Platelets. Stroke. Cerebrovascular Accident.

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