Aakif Ullah Khan, Tin Maung Thein, Amjad Aziz Khan, Sher Muhammad Khan.
Role of locally formulated 131I-MIBG in imaging of neuroendocrine tumors
J Coll Physicians Surg Pak Oct 2001;11(10):617-21.
Department of Nuclear Medicine, Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar
Objective: To evaluate the clinical utility of locally formulated kits of Radioactive Iodine-131 labeled Meta-iodo-benzyl-guanidine (131I-MIBG) in the imaging of neuro-endocrine (NE) tumors. Design : It was an observational and experimental study. Place and Duration of Study: The study was conducted at Nuclear Medicine Department, Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar from May, 1997 to April, 1998. Subjects and Methods: A total of 25 patients, 20 males and 5 females, were included. Majority of the patients had histologically proven diagnosis of NE tumors and were referred to IRNUM for further management of residual mass or metastasis. Some of the cases were evaluated for suspected NE pathology and followed prospectively. Results: Out of 10 neuroblastoma (NB) cases, 7 showed true positive uptake, 2 showed true negative uptake and one was found to be false negative. All the 3 cases of medullary carcinoma thyroid (MCT) showed positive uptake. None of the 3 paragangliomas and one of the 2 carcinoid tumor cases showed no 131I-MIBG uptake, however, both of pheochromocytoma were correctly localized and diagnosed. None of the 5 cases of non-specific and equivocal histopathology showed any evidence of 131I-MIBG accumulation adding to the diagnostic dilemma. Conclusion: 131I-MIBG scintigraphy is valuable tool in the imaging of NE tumor especially NB, MCT and pheochromocytoma and the locally formulated kits proved useful and of adequate quality clinically.
Category: Nuclear Medicine
Keywords: Radioactive Tracers. Neuroblastoma. Pheochromocytoma. Paraganglioma. Carcinoid Tumor.
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