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Excessive Dietary salt; Cause of many fatal diseases

Excess dietary salt is associated with insulin resistance and hypertension, and may lead to type 2 diabetes, cardiovascular disease and chronic kidney disease. The mechanisms underlying the pathogenic effects of salt on the cardiovascular system include impaired glucose homeostasis and activation of the sympathetic nervous system and renin-angiotensin-aldosterone system. Mineralocorticoid receptor blockers are promising therapies to counteract the adverse metabolic and cardiovascular effects of salt.

For details
http://www.nature.com/nrcardio/journal/v7/n10/full/nrcardio.2010.123.html