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chameed

Re: Clinical trial on Hepatitis C

I'm confused a bit here. Is the trial on Hepatitis C related Cirrhosis? or is it on patients with Cirrhosis? If these patients are so decompensated that the alternative is liver transplant, how are they being kept alive?

lachvi

Re: Clinical trial on Hepatitis C

I agree with Saeedkhan that discussion is going in wrong way. We should be cool and polite. Research is very difficult and tiring job. You have to be answerable for each and evry step you take. I think the reserach work should be properly planned fulfilling all the prerequisites. The approval of an ethical apptoval is mandatory specially in interventional trial. Having said that ,it is a fact that we face problems in getting approval from ethical committees as the existing committees{if any } are very lethargic in replying. What we need are ethical committees at the distt level, teaching hospital and provincial level.

zhussain

Re: Clinical trial on Hepatitis C

Any research should first be approved by a ethical committee to make sure the research is ----------well ethical!!Does such a body of experts exist

saeedkhan

Clinical trial on Hepatitis C

The discussion has gone in a wrong way and the original question has not been properly answered. The "research" as is being carried out can only be published as a letter to editor only when a related article has already appeared in a journal. In such a situation, it will be the experience of the writer and not the research.
One can carry out the research (and draw conclusions) in a way he likes. But for publication, it must follow a rigidly prescribed routine. The case being discussed falls under a clinical trial. In such cases if only one drug is to be tested then a minimum of two groups are necessary. One group of patients should receive placebo, preferably consisting of the base in which the drug is prepared. The other group will receive the drug treatment. The patients should be allotted to the two groups in a proper random way. They should be explained about the trial and should volunteer for the treatment. The results of the treatment should be measured by another person who does not know the grouping of the patients. Finally when the results are tabulated, then it must be determined whether the observed effect is actual or it could be by chance.
Without this protocol, treating 'x' number of patients with 'y' drug(s) and reporting 'z' results cannot be published.

zhussain

Re: Clinical trial on Hepatitis C

Sorry for the delay in replying.
You are assuming that all the poor patients in this obnoxious trial(if you can call it that)have end stage liver disease---the gentleman doing this so called trial does not mention that!