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Topic Review - Newest First (only newest 5 are displayed)

oncoman

Re: What is your diagnosis

Mantle cell lymphomas are incurable. There are two histologic types-nodular and diffuse. Median survival for nodular is about 5 year and diffuse approx 2 years. Leukemic phase would represent a more advanced stage and probably fall in 2 year category.
Chemotherapy with CVP or CHOP is therapy of choice. More data is now available to add Rituximab (monoclonal antibody against CD-20) may improve response rate but not induce cure. Again emerging data supports autologous stem transplant after high dose chemotherapy in selected patients.

memon

Re: What is your diagnosis

So What is the treatment of choice and prognosis?

docosama

Re: What is your diagnosis

thanks!

oncoman

Re: What is your diagnosis

Just for conpletion sake other markers to look for would be
Surface immunoglobulin light chain restriction which is typically weak in expression and also a marker of monoclonality
CD 79b
FMC-7

oncoman

Re: What is your diagnosis

Good differential with CD 5+ and CD 20+ but CLL is CD23+ as well. This is not CLL. The phenotype is that of a mantle cell lymphoma. Mantle cell though usually presents in lymph node but all lymphomas and specially Manlte cell has a leukemic phase which may herald the terminal stage of the illness.