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Gene expression by flow of blood
Physically expression of the Gene
Researchers at the University of Pennsylvania School of Medicine have pinpointed a key regulatory protein that translates blood flow into gene expression. The investigators showed that in a model of mouse embryonic development a transcription factor called Klf2, which resides in cells that line blood vessels, is activated by rapid, pulsed blood flow, as reported in the December issue of Developmental Cell. Understanding Klf2's role in blood vessel and muscle biology could help with fighting atherosclerosis.
There are many other phsycal ways of gene expression, like when temperature of the cell environment is increased cell release heat shock proteins and many others but this is first time discovered that the blood flow can also cause the expression of some gene in blood vessels muscles.
For rest of the story please click below
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=24600015
Best regards
Aftab Ahmad
Posted by: aftabacPosts: 271 :: 28-12-2006 :: | Reply to this Message
Re: Gene expression by flow of bloodThis is an intersting topic but for the correction of record, this is not the first report of Kruppel-like factor 2 (Klf2) regulation by blood flow. This phenomenon was reported by Groenendijk et al in the journal 'Circulation Research' in June 2005, by Dekker et al in the journal 'American Journal of Pathology' in August 2005, and by Parmar et al in the journal 'Journal of Clinical investigation' in Jan 2006.
Posted by: rqayyumPosts: 199 :: 29-12-2006 :: | Reply to this Message
Re: Re: Gene expression by flow of blood
AoA
Thanks for updating me,
well, its pretty good that our docotors are in touch with latest clinical research.
best regards
aftab
Posted by: aftabacPosts: 271 :: 10-01-2007 :: | Reply to this Message