Viroj Wiwanitkit.
A study on functional similarity between Dengue non structural protein 1 and platelet integrin/adhesin protein, CD61.
J Ayub Med Coll Abottabad Jan ;18(3):13-6.

Background: Dengue infection is a major public health problem. The mechanisms underlying severe bleeding in dengue DHF are not completely understood. It was proposed that the dengue virus nonstructural-1 protein (DNS1) generated antibodies to common epitopes on human blood clotting and integrin/adhesin proteins on the platelet. The proof on the functional correlation between DNS1 and platelet integrin/adhesin proteins is needed. Methods: Here, the author used a new gene ontology technology to predict the molecular function and biological process of DNS1 and platelet integrin/adhesin protein, CD61. Result: According to this study, the author can identify no function and biological process of DNS1. Also, there is no existence of functional similarity between DNS1 and CD61. Conclusion: The hypothesis on role of molecular mimicry between DNS1 and CD61 is not supported in this study.

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