Najma Sultana, Saeed Arayne, Aisha Sana.
Fosinopril H2-receptor antagonists interaction studies by derivative Spectroscopy.
Pak J Pharm Sci Jan ;20(1):19-25.

Fosinopril sodium, a phosphinic acid derivative is an angiotensin converting enzyme (ACE) inhibitor, which had been employed for the treatment of hypertension and congestive heart failure; long tem use of ACE inhibitor often result in stress ulcers due to which H2 receptor antagonists are also concurrently prescribed. The later compete with histamine for H2 receptors and block gastric acid secretion and some cardiovascular effects of histamine. Our studies are focused on the in vitro availability of fosinopril in presence of commonly used H2 receptor antagonists. Derivative spectroscopy has been employed for the quantitation of fosinopril and H2 receptor antagonists followed by linear regression analysis. These studies were carried out in buffers of pH 7.4 and 9 at 37, 48 and 60ºC. Stability constant and thermodynamic function had also been calculated in order to evaluate the reaction mechanism. Commonly prescribed H2 receptor antagonists like cimetidine, ranitidine and famotidine were used in these studies. Present study clearly indicated that most of the H2 receptor antagonists studied decreased the availability of fosinopril which conclude that availability of fosinopril can be affected by the concurrent administration of H2 receptor antagonists.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com