Parvizi R, Rahbani Noubar M, Hassanzadeh Salmasi S.
Oxidative stress and Homocysteine metabolism following coronary artery grafting by on pump and off pump CABG techniques.
Rawal Med J Jan ;32(1):3-7.

Objectives: To compare the effect of on-pump and off-pump CABG on the induction of the oxidative stress and the metabolism of homocysteine, which is involved in the synthesis of glutathione. Methods: This retrospective study was performed in Shahid Madani Heart Hospital in Tabriz, Iran in 2004 using a questionnaire. Plasma homocysteine, folate total antioxidant capacity (TAC) and malonedialdehyde (MDA) were determined on blood samples obtained from 40 patients undergoing CABG, preoperatively and at 0,12,48,120 hours and 6 months after surgery. The patients were divided into two matched groups, one off-pump and the other on-pump CABG. Results: A marked reduction of homocysteine, folate and significant elevation of MDA were noticed at 0, 12, 48 hours after operation in the both groups (P<0.05). A negative and marked correlation between homocysteine and TAC but a positive and significant between homocysteinc and MDA were observed (P<0.05 in the both groups). Conclusion: In CABG operation because of oxidative stress and consumption of GSH immediate reduction in the plasma levels of homocyticine occurs in the both techniques. However using off pump CABG induction of oxidative stress and changes in plasma levels of homocysteine are not as high as on- pump CABG. (Rawal Med J 2007;32:3-7)

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