Humaira Tariq, Tariq Sarfraz.
Fertility following Polycystic Ovarian Syndrome.
Pak Armed Forces Med J Jan ;57(1):96-7.

A 27 years old lady, reported for the treatment of her infertility. For the last one year she noticed a change in her menstrual cycle. Previously, she had 5 -6 bleeding days after every thirty days. She had gained weight during the last year and had body mass index of 27. Her thyroid was clinically normal and there was no galactorrhoea. On ultrasound, Ovaries were bilaterally enlarged with scattered peripheral cysts. Serum FSH and LH levels were normal as were thyroid function tests and serum testosterone levels. She was put on half tablet Glucophage (Metformin) twice daily and tablet Diane 35. She was advised dietary changes and life style modifications. After four months of treatment, her physical symptoms improved and she lost five kilograms of weight. She was then put on tablet Clomid (Clomiphene Citrate) 50mg once daily for five days from 2nd to 5th day of cycle. Coital advice was given to the couple. She had her first missed periods after two months of ovulation induction therapy. Her urine pregnancy test was positive at 5 weeks of amenorrhoea but she had abortion at the end of her 6th week of amenorrhoea. Two months following her abortion, she was again put on Clomiphene Citrate therapy and she conceived again. She was put Injection Profassi (Human Chorionic Gonadotrophin) 5000 IU weekly and tablet Dirogest (Dydrogesterone) three tines daily for luteal phase support. She continued with a normal pregnancy.

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