This is a prospective study conducted on patients visiting out patient Rheumatology Clinic at National Hospital and Medical Centre, Lahore from 1996-2000. Only those patients with active SLE or RA were included in the study who were taking chloroquin and who received regular eye examination including examination of visual fields, colour vision, slit lamp examination and fundoscopy. All of these patients had base line eye examination and subsequently repeat eye examinations were carried out every 3 months by qualified opthalmologists. RESULTS: Ocular toxicity was seen in 9 patients. The statistical analysis show that both the causes with toxicity and controls without toxicity were comparable in terms of all the parameters evaluated. It is interesting to note that controls that did not have any toxicity were, in fact, receiving higher mg/kg dose as compared to the cases although the difference between the two groups was not statistically significant. However, the mean total dose given to the controls was slightly less than that of the cases. The study did not attempt to look into the possible causes of this peculiar observation.
PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com