Isam Hamo Mahmood.
Serum Uric Acid Concentration in patients with Type 2 Diabetes Mellitus during Diet or Glibenclamide Therapy.
Pak J Med Sci Jan ;23(3):361-5.

Objective: To investigate serum uric acid concentration in patients with type 2 diabetes mellitus. Methodology: This is a case control study conducted in Al-Wafa Diabetic Center in Mosul over a period of one year starting from January 1, 2005 to January 1, 2006. Serum glucose concentration and uric acid concentration were measured in both control and patient`s groups (group 1 patients on diet therapy, group 2 patients on glibenclamide therapy and group 3 involve naturopathic patients). Results: Serum glucose concentration was high in the diabetic groups as compared with the control group (P<0.001). Serum uric acid concentration was lower in the diabetic groups as compared with the control group but do not reach a significant level (P>0.2) except in group-3 (P<0.05). A negative correlation was reported between hyperglycemia and uric acid concentration of the different groups. Conclusion: Serum uric acid concentration is slightly reduced in type 2 diabetic patients particularly in the complicated patients with peripheral neuropathy and this may be due to the oxidative stress that decreases the antioxidant capacity of the body involving uric acid.

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