Aleyasin A, Am Mobarez, Sadeghizadeh M, Sseini Doust R Hosseini, Khoramabadi N.
Resistance to vancomycin in enterococcus faecium and faeca lis clinical isolates.
Pak J Med Sci Jan ;23(3):390-3.

The aim of this study was to investigate antibacterial resistance among enterococci species isolated in Tehran Baghyatallah Hospital. It consisted of 126 isolates of E. faecalis (86%), E. faecium (9%) and other Enterococus Spp. (5%) isolated from urine (34.92%), blood (27.77%), wound swabs (19.84), stool (5%) endotracheal secretions (3.37%), abscess (3.4%), dialysis fluids (1.7%) and catheter (4%). Twelve (9.5%) isolates were resistant to vancomycin. The VRE isolates were resistant to ampicillin (75%), erythromycin (50%), tetracycline (58%), ciprofloxacin (41.6%), chloramphenicol (33.3%) and gentamicin (41.6%). Two (16.66%) of VRE isolates were multidrug resistant. Eight (66.6%) of the vancomycin-resistant strains and all of the MDR strains carried the vanA phenotype and genotype. The MIC of VRE isolates were between 32-512µg/ml. Our results show that most glycopeptide resistant E. faecalis and E. Faecium carried vanA. It is also possible that frequency of infections caused by glycopeptide-resistant enteroco cci will increase in our geographical area.

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