Khalil Ullah, Tariq Mahmood Satti, Parvez Ahmed, Shahid Raza, Waheeduz Zaman Tariq, Muhammad Khalid Kamal, Qamarun Nisa Chaudhry, Farrukh Mahmood Akhtar.
Successful allogeneic stem cells transplantation in severe aplastic anaemia complicated by dengue fever.
J Coll Physicians Surg Pak Jan ;17(10):635-6.

Aplastic anaemia is characterized by severe compromise of haematopoiesis and hypocellular bone marrow. Haemorrhagic episodes in patients with aplastic anemia occur usually secondary to thrombocytopenia and require frequent support with platelet concentrates and other blood products. Infection with dengue virus (particularly dengue sero type-2 of South Asian genotype) is associated with dengue haemorrhagic fever. Dengue infection further worsens the disease process in patients with aplastic anaemia due to uncontrolled haemorrhagic diathesis and major organ failure, which may prove fatal in these already immunocompromised patients, if not treated in time. Recent epidemics of dengue haemorrhagic fever has not only affected the southern region of our country but also spread to other areas of the country. With this background, we report a case of aplastic anaemia complicated by dengue haemorrhagic fever who achieved successful engraftment after allogeneic stem cell transplantation from sibling brother and is having normal healthy post transplant life.

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