Shahnam Askarpour, Massoud Dehdashtian, Saeed Marashi.
Effect of oral glucose and the response to pain in the term neonate.
Pak J Med Sci Jan ;23(5):733-5.

Objective: If neonates are exposed to severe pain or long duration pain stimulus, it may increase morbidity. Infants who experienced pain during neonatal period, will response intermittently to pain during next painful events. In the newborn and young infants who have undergone painful minor surgery, oral sucrose will provide safe way to analgesia. The aim of this study was to evaluate effect of oral glucose on the reduction of pain in neonates. Methodology: All of the neonates aged 2-10 days and weighted >2500gm who were admitted for phototherapy and bilirubin and were not in the range of exchange, were included in this study. This study was carried out in department of neonatology of Abuzar Children Hospital and Imam Khomeini hospital. One hundred eight neonates were included. Each neonate was fed through a syringe every 30 minutes with 2ml of distilled water, D/W10%, D/W20%, D/W50% on the anterior portion of the tongue. Immediately, a lancet was injected into the heel of neonate and changes in the face and crying was recorded for three minutes after injection. Wong criteria was used for assessment of changes in the face and crying. The type of this study was Quasi- experimental and Fischer- exact test was used for data analysis. Results: From 108 neonates who were fed with distilled water, D/W 10%, D/W20% and D/W50%; 1(0.9%), 41(28%),101(93.5%), and 106(98.1%) showed decreased pain sensation respectively. Conclusion: The results of this study revealed that oral glucose is the safe analgesic agent and is recommended for use in the neonatology ward before painful procedure.

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