Mazhar Mushtaq, Prof Saghir Ahmed Jafri, Abdus Salam Sheikh, Sadia Ahmad, Farah Deeba, Khurram Salam.
Human Chorionic Gonadotropin (hCG): A treatment of oligospermia.
Pak J Med Sci Jan ;23(5):840-6.

The most commonly accepted definition of the term infertility is the lack of pregnancy (regardless of cause) after one year of unprotected intercourse. Infertility affects approximately 15% of couples of reproductive age. Its prevalence has been stable during the past 50 years, although a shift in etiology and in the age of the patient has occurred. In Pakistan there are roughly 10-15% newly married couples who require some kind of medical help before they can become parents. Even if the wife is fertile and the husband is normal, there is roughly 1 in 3 chances the wife will conceive. A total of 17 patients were diagnosed for Oligospermia and were placed in one group. 5000 IU of hCG were administered intramuscularly once a week for four month. Every month serum testosterone and semen count was analyzed. Progressive increase of semen count was observed in four month. hCG though, never produced in male but has significant effect on spermatogenesis via LH receptor. Initial value of 25 million/ml roused to 69 million/ml in just four month. Use of hCG in male infertility is though common world wide but it has not gained its popularity in Pakistan. General awareness of its usage especially among physicians treating infertility is required.

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