Abdel Nabi Albdour, Hakam Akasheh, Tameem Aljayousi.
Missed abortion: Termination using single-dose versus two doses of vaginal misoprostol tablets.
Pak J Med Sci Jan ;23(5):920-3.

Objective: To determine the effectiveness of 400µg misoprostol, administered vaginally as single-dose, compared to repeating the same drug, six hours later, for termination of missed abortion. Methodology: One hundred ninety eight women with missed abortion were enrolled in this study. They had presented to Prince Zeid, Prince Rashed and Queen Alia Military Hospitals from June 1, 2005 to September 30, 2006 for termination of pregnancy. The gestational ages ranged between 9-22 weeks. Ninety three women were assigned to the single-dose group (Group-I) while the rest were given two doses of 400µg misoprostol, six hours apart (Group-II). Results: The success rate for Group-I was approximately 88% compared to around 94% in Group-II. In Group-I, of all the women who aborted, about 50% had complete abortion compared to 66% in Group-II. The average time interval from the start of termination to expulsion of conception was around 13 hours in Group-I and 9 hours in Group-II (p <0.05). Only minimal adverse effects were noted. Conclusion: Two doses of 400µg misoprostol administered vaginally did not prove to be superior to a single dose for termination of missed abortion, however, more women who had a successful procedure in Group-I needed evacuation and curettage. The mean abortion time was shorter in Group-II.

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