Afshan Chaudhry, Ghulam Rasool Mashoori, Tabassum Zehra, Najma Naz, Jamil Laghari.
Comparative dose efficacy study of Atorvastatin versus Simvastatin and Lovastatin in primary hyperlipidemic patients.
Med Channel Jan ;14(1):40-4.

OBJECTIVE: The objective of this prospective study was to evaluate the comparative dose efficacy of the 3-hydroxy-3 -methyl-glutaryl coenzyme A(HMG-CoA) reductase inhibitor Atorvastatin 10mg compared with Simvastatin and Lovastatin of the same potency. BACKGROUND: Atorvastatin has multiple mechanisms of action and longer half life that could potentially contribute to its better efficacy as compared to other statins. We conducted a randomized, open table, prospective study to assess the efficacy of tab Atorvastatin in hyperlipidemic patients of Pakistani population as compared to Simvastatin and Lovastatin of the same potency. METHODS AND MATERIALS: Patients diagnosed with primary hyperlipidemia and, having total cholesterol more than 200mg/dl and triglycerides levels <400mg/dl were enrolled (66) and divided into three groups. Group DRI received tab Atorvastatin 10 mg, DR2 received tab Simvastatin 10 mg, and DR3 received tab Lovastatin 10 mg for 90 days. These patients were on lipid lowering diet but were not normalized in tern: of LDL-cholesterol. At the end of study period the parameters examined were serum low -density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and triglycerides (TGs) levels. RESULTS: Atorvastatin at a dose of 10mg/day produced: (1) a significant reduction in LDL-cholesterol (-35.97%) in comparison with equivalent doses of Simvastatin (- 27.22%). and Lovastatin (-23.75%); (2) a significantly greater reduction in total cholesterol (27.58%) than that obtained with Simvastatin (-20.00%), and Lovastatin (- 18.03%); (3) HDL-cholesterol increase (8.12%) comparable to or greater than those obtained with Simvastatin (7.81%), and Lovastatin (6.54%); (4) a significantly greater reduction in triglycerides than obtained with other two drugs. All the three reductase had similar levels of tolerance. CONCLUSION: Atorvastatin in the most effective drug to reduce serum cholesterol serum triglyceride and LDL- cholesterol and to increase HDL cholesterol than Simvastatin and Lovastatin of the same potency. Its more effects may be due to its longer half life..

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