Farida Wagan, Ghulam Nabi Memon, Shams Raza Brohi, Razia Bahadur Khero, Shaheen Shah.
Gestational trophoblastic disease: a clinical study.
Med Channel Jan ;14(1):59-61.

OBJECTIVE: of this study is to evaluate the risk factors associated, common presentations and treatment modalities of trophoblastic diseases. DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: This study was conducted in department of Obstetric and Gynecology at NMCH Nawabshah from June 2002 to May 2003. PATIENT AND METHOD: The case records of all patients with trophoblastic disease were analyzed retrospectively regarding age, parity, sign symptom, duration of previous treatment, histopathology finding, investigations, type of trophoblastic disease, treatment modalities, follow up and mortality associated with this disease. RESULT: Total number of 2963 pregnancy related patient were admitted in our hospital during this year, in which 18 patients had trophoblastic disease. So the frequency generation of trophoblastic disease was 8.6/1000 live births, most of patient belonged to the extreme of ages and had high parity. The commonest presentation was bleeding per vagina 100% (18 patients) followed by pain in lower abdomen 77.767% (14 patients). 3 patients had hyperemesis gravidarum ie16.66 % and 2 patients had hypertension ie 11.11%. The incidence of hydatidiform mole was 77.77% (16 patients) , invasive mole was one ie (5.5%) and same for choriocarcioma i.e. one patient. All patients underwent surgical treatment. 17(94.47%) patients had suction evacuation and one patient had hysterectomy. 15(83. 33%) patients received no adjuant therapy, while 3 (16.67%) received chemotherapy follow up with chemical examination and investigation such as serum B-HCG. In patients having benign GTD the serum B-HCG level was undetectable with in 3 month period. CONCLUSION: It is concluded from our study that GTD is associated with extreme of reproductive life and high parity. Early diagnosis and meticulous treatment by Suction curettage and chemotherapy in selected patient with follow up by B-HCG level are the keys of success in management of GTD.

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