STUDY OBJECTIVE:- To determine the frequency of helicobacter pylori among patients with peptic ulcer disease. STUDY DESIGN:- Prospective observational study. SETTING:- Liaquat University Hospital Hyderabad / Jamshoro. The study conducted from 1.7.2004 to 30.6.2005. MATERIALS & METHODS:- 50 patients of peptic ulcer disease (39 of duodenal ulcer and 11 of gastric ulcer), who were admitted in the ward or attending the out patient department, were included in this study. Out of 50, 33 were males and 17 were females (mean age: 44.5 ) (standard deviation 24.5). The patients selection criteria over barium meal or endoscopy. After written consent all patients were subjected to complete history taking and thorough clinical examination. Laboratory investigations included complete blood count and stool for occult blood. Upper GI Endoscopy was performed in even patient and five mucosal biopsies were taken. Helicobacter pylori was detected by histology, rapid urease test, culture and serology in every patient. All these findings were entered in a performa. Data analysis was done by using SPSS 10.0 statistical software and results were finally checked by test of significance. RESULTS:- Out of 50 patients, anemia (Hb < 10 gm/dl) was positive in 32% and stool for occult blood was positive in 14% patients. The results showed coexistent endoscopic findings in 90% patients (gastritis and gastroduodenitis). The results of diagnostic tests revealed that helicobacter pylori was present in 88% patients with peptic ulcer disease (90.9% males and 82.2% females). The test of significance came out as p-value <0.05. The relative frequency of H. Pylori among patients with gastric ulcer was 70% and 90% in duodenal ulcer. CONCLUSIONS:- The results concluded a strong relation ship between HP and PUD and it is more common in duodenal ulcer than gastric ulcer and its frequency increases with the increasing age.
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