Sadia Amir, Zamir Ahmed, Adina Shamsi, Kokab Sultana, Quratul Ain.
Maternal plasma Homocysteine level, 24-Hour urinary protein and hemoglobin in Pre-eclamptic patients: Is there any relationship?.
Esculapio J Services Inst Med Sci Jan ;2(2):26-8.

Background: Anaemia is very common in developing countries especially during pregnancy. Hyperhomocysteinaemia can result from genetic or nutrient-related disturbances in the transsulfuration or remethylation pathway for homocysteine metabolism. Inadequate intake of vitamin B ,B or folate may underlie some cases of elevated homocysteine levels. The aim of this 12 6 study was to investigate the possible relationship between plasma homocysteine level, haemoglobin level and 24-hour urinary protein in pre-eclamptic patients. Folic acid deficiency is one of the major causes of hyperhomocysteinemia which is one of the major risk factor for preeclampsia [PET]. Severe proteinuria of several grams/day occurs in pre-eclamptic toxaemia. Methods: A cross-sectional comparative study was carried out on 90 primigravida attending the "antenatal clinic" of Services Hospital,Lahore. Results: Out of these 60 primigravida 30 were mildly preeclamptic and 30 were severely pre-eclamptic at 30-38 weeks of pregnancy.30 primigravida [30- 38 weeks of pregnancy] having uncomplicated pregnancy were taken as control. Conclusion: The results show that in mild PET and in severe PET, the plasma homocysteine level shows a significant relationship with 24-hour urinary protein and haemoglobin level. Anaemia [folic acid defeciency] is one of the important risk factor in the causation of hyperhomocysteinemia which is one of the major chronic risk factors for eclampsia.

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