Mehrun Nisa, Masood Alam, Muhammad Zubair, Sh Muhammad Ashfaq.
Noninvasive Study of Left Ventricular Filling in Normotensive Obese Adults.
Ann King Edward Med Uni Jan ;7(1):14-7.

This study was conducted to determine the influence of uncomplicated obesity on left ventricular (LV) diastolic filling. Indexes of LV diastolic filling were measured by pulsed Doppler echocardiography in 46 normotensive moderate to severely obese (BMI 30-44 kg/m2) subjects and were compared with an age, height and sex matched lean control subjects. No obese subject had any disease known to affect diastolic function. All subjects had normal systolic function. Forty-three percent of obese subjects had LV hypertrophy, while fifty eight percent had LV diastolic filling abnormalities. These were (1) peak early diastolic flow velocity (PEFV) or E-wave significantly reduced in obese subjects (89.85±2.2 Vs 65.59±2.4 cms/sec, p<0.001) (2) prolonged deceleration time of E-wave (E-Dec time) (190±2.8 vs 211.2±5.3 msec, p<0.001), (3) reduced E/A ratio (1.59±0.0046 Vs 1.095±0.003, p<0.001). In conclusion, obesity is associated with preclinical abnormalities of Doppler derived diastolic filling indexes which may reflect impaired relaxation of LV. Their finding may be useful in early detection of LV dysfunction in obesity.

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