Seema Mazhar, Muhammad Tayyab, Tahira Tasneem, Zafar Iqbal, Khalid Waheed, Naseer Ahmed Chaudhry.
Abnormalities of Platelet Aggregation in Acute Myocardial Infraction..
Ann King Edward Med Uni Jan ;7(1):67-9.

Platelet have been implicated in the formation of occlusive intracoronary thrombi leading to acute myocardial infraction (MI). Evidence of platelet involvement is shown by enhanced in vitro sensitivity to agonists. 70 patients of acute myocardial infraction were selected from casualty departments of Mayo Hospital, Services Hospital and Punjab Institute of Cardiology. The aggregation response of platelets to collagen and ADP was measured. The values of percentage aggregation, slope of aggregation, threshold concentration and spontaneous aggregation were compared with 30 healthy age and sex matched controls. 66 (95%) patients had enhanced values of percentage aggregation and rate of aggregation with different concentrations of ADP (1,2.5,5 & 10 pmol) and collagen (1,2,4 mcg) used. Only 3 (10%) of control subjects had enhanced values. Similar were the observations with spontaneous aggregation in both the groups. The mean threshold concentration value with ADP was 1.1 pmol in patients as compared with the control value of 4.94mcmol. Platelet count was in upper normal range (350-3.15x10e9/1) in 41 (58.3%) patients and 3 (10%) controls. All the above values thus differed significantly between patients and controls (P<0.001). We suggest that platelet hyperaggregability and high platelet count may be responsible for the onset of acute (MI) due to the development of coronary thrombotic obstruction.

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