Sadqa Aftab, Shamsunnisa Rashdi, Jamil Akhtar Abdul Bari Khan.
Comparison of intravenous ketorolac with diclofenac for postoperative analgesia.
J Surg Pak Jan ;13(2):62-6.

Objective: To compare analgesic effect and complications of non - steroidal anti-inflammatory drugs (NASIDs), ketorolac versus diclofenic in prevention of pain after laparoscopic cholecystectomy. Design: Quasi-experimental study. Place and duration of study: The Department of Anesthesiology and Surgical Intensive Care Unit, Dow Medical College, Karachi from March 2003 to March 2004. Patients and Methods: Sixty patients, ASA physical status I and II were selected to received either ketorolac 30 mg intravenous (group A) or diclofenic 75 mg intravenous (group B), after general anesthesia induction and before surgical incision. In ketorolac group same dose repeated three times daily for 24 hours. The diclofenic group received diclofenic 75mg 12 hourly for 24 hours. Analgesic effect assessed by intensity of pain postoperatively using visual analogue scale, 0 mean no pain and 10 most severe pain. Rescue analgesic nalbuphine was administered if needed. Results: Both groups required rescue analgesic 0.1mg/kg nalbuphine boluses postoperatively. Higher nalbuphine consumption was noted compared to diclofenic group until 12 hours, which is statistically significant (P value < 0.05). Side effects were almost similar in both groups. Conclusions: Ketorolac and diclofenic are insufficient alone for analgesia after laparoscopic cholecystectomy; the total nalbuphine consumption was less in ketorolac group.

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