Asadi Shekaari Majid, Panahi Marzieh, Dabiri Shahriar, Safi Khani Zahed, Kalantaripour Taj Pari.
Neuroprotective effects of aqueous date fruit extract on focal cerebral ischemia in rats.
Pak J Med Sci Jan ;24(4):661-5.

Objective: Many neuroprotective agents are introduced to protect neurons against oxidative injury. Aqueous Date Fruit Extract (ADFE) is a potent antioxidant agent. This study was designed to investigate neuroprotective effect of ADFE in focal cerebral ischemia in rats. Methodology: Rats were fed with different doses of ADFE by gastric intubation daily for two weeks. After feeding, right middle cerebral artery was ligated for 30 minutes followed by 48 reperfusion. Then animals were sacrificed and brains removed for Nissl staining. Neuronal damage was then estimated in three distinct areas of CA1 of hippocampus subfield. After determination of ADFE optimal dose, immunohistochemistry was performed for p53 expression. Results: The optimal dose of ADFE significantly inhibited neuronal damage induced by cerebral ischemia. Conclusion: The results may suggest that the effectiveness of ADFE in focal cerebral ischemia is most probably due to its antioxidant property.

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