Amina Hamed Ahmad Al Obaidi, Abdul Ghani Mohamed Al Samarai.
The predictive value of Eosinophil cationic protein in asthma as marker of poorly controlled disease and response guide to treatment.
Pak J Chest Med Jan ;14(2):11-7.

Background: Asthma is an inflammatory disease that involves local and systemic inflammation. Eosinophil cationic protein [ECP] is a marker of eosinophilic inflammation in asthma. Objective: To clarify the validity of ECP determination as predictor of poorly controlled or relapsing asthma. Patients and Methods: Twenty six asthmatic patients were included for poorly controlled asthma, while 12 patients were included in relapse study. ECP were determined using ELISA. Results: Asthmatic patients with poorly controlled asthma had significantly (P<0.0001) higher sputum and serum ECP than that in stable asthmatic. Mean serum ECP of asthmatic patients was significantly higher than that in asthmatic patients without relapse. Conclusion: Serum and sputum ECP as eosinophilic inflammatory markers are associated with poor asthma control and may be used as additional marker for disease control response guide to treatment.

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