Muhammad Rafique Cheema, Muhammad Ashraf.
Head injury;.
Professional Med J Jan ;15(4):445-8.

Abnormal coagulation and fibrinolysis is a complication observed in individuals having traumatic brain injury. Objectives: To evaluate the incidence of this complication. Design: Retrospective and comparative study. Setting: Lahore general Hospital Lahore. Period: From 1995 to 2000. Materials & Methods: One hundred adults, both male and female, having traumatic brain injury, admitted in Lahore general Hospital Lahore were subjected to estimation of prothrombin time, activated partial thromboplastin time and fibrin degradation products 48 hours after injury. Results: Fifty control and thirty three patients with severe head injury were studied. Prothrombin time in 17 patients was prolonged. Which was statistically significant. APTT was prolonged in four cases when compared with normal. FDP were increased in 51% cases. This elevation was again significant statistically. Conclusion: Significant changes in prothrombin time and fibrin degradation products were observed after 48 hours of brain injury.

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