Azeem Hashmat, Tahira Ishfaq.
Anal fissure;.
Professional Med J Jan ;15(4):420-4.

To evaluate the efficacy of glyceryl trinitrate (GTN) preparation for the treatment fissure in-ano. Design: This study is a prospective clinical trial. Place and duration: this was conducted initially at PMC Faisalabad and other centers from November 2001 to onward for the period of five years. Patients and Methods: Out of 306 patients, 42 disliked/ refused this modality of treatment and was launched on 264 patients. 114 patients never followed up so, were excluded from the study. The remaining 276 patients applied 0.2% glyceryl trinitrate preparation on their anal verge thrice a day for two months. The patients were followed up at 1 to 12 weeks. The extent st th of improvement in the presenting symptoms, side effects and complications were noted on questionnaires. Results: A healing rate of 64.3%, and recurrence occurred in 35.7 %. 72 patients demanded surgery after failure/ non-compliance of GTN ointment treatment. Conclusion: glyceryl trinitrate preparation is a safe and effective modality for the treatment of fissure in-ano.

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