Majid Zarrin, Mahmoud Jamshidian, Mohammad Jafari.
In vitro interactions of miconazole with sulfametoxazole against candida species.
Pak J Med Sci Jan ;25(2):243-6.

Objective: Finding the synergism effect of miconazole and sulfametoxazole on 4 species of candida. Methodology: Interactions of miconazole in combination with sulfametoxazole were tested in buffered yeast-nitrogen base using checkerboard method. Plates were inoculated with 20µl cells suspensions of each yeast and incubated at 30°C for 24 hour. In this method, the MICs were described as the lowest antimicrobial concentration inhibiting visible fungal growth on the plates. Minimal fungicidal concentration (MFC) was described as the first tube showing no growth on the plate. Results: The MIC of miconazole was 11.30µg/ml for Candida albicans. 8.9µg/ml for Candida tropicalis 8.6µg/ml for Candida papapsilosis and 5.2µg/ml for Candida krusei. When miconazole were combined with sulfametoxazole, miconazole MICs decreased to 1.54µg/ml for C. albicans, 0.5µg/ml for C. tropicalis, 0.383µg/ml for C. parapsilosis and 0.275µg/ml for C. krusei. Conclusion: The data show that combination of miconazole and sulfametoxazole was synergistic on C. albicans, C. tropicalis, C. parapsilosis and C. krusei.

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