Liaquat Ali, Raja Mushtaq.
Laryngoscopy and tracheal intubation.
Professional Med J Jan ;12(3):267-72.

To assess the efficacy of IV Lignocaine in a dose of 1.5 mg/kg to attenuate the haemodynemic response of laryngoscopy and tracheal intubation. Design of study: A control interventional prospective study. Setting: CMH Gujranwala and CMH Muzaffarabad. Period: Jan 2004 to Dec 2004. Method & materials: 120 ASA I & II patients anaesthetized with thiopentone sodium and suxamethomium. Patients were allocated randomly to a control group or three treatment groups to receive lignocaine 1.5 mg/kg I. V, 3,2, minutes respectively before laryngoscopy. Results: Maximum increase in heart rate was 1 minute after laryngoscopy and intubation in all four groups (21-30%). There was no significant difference between the groups. Maximum rise in MAP was also 1 minute after laryngoscopy and intubation averaging 31.2%, 25%, 26.9%, 26.4% in group I, II, II, IV respectively. There was no significant (P>.05) difference in the rise of mean arterial pressure(MAP) in patients receiving IV lignocaine when compared with the control group. Conclusions: IV lignocaine in a dose of 1.5 mg/kg starting 3 minutes before laryngoscopy and intubation does not suppresses significantly, the increase in MAP and heart rate , during laryngoscopy and endotracheal intubation.

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